GRB10 Antikörper (N-Term)

Produktnummer ABIN1881389

Produktdetails anti-GRB10 Antikörper

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GRB10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GRB10.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GRB10 Antikörper (ABIN1881389)

Nantel, Mohammad-Ali, Sherk, Posner, Thomas: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).

Frantz, Giorgetti-Peraldi, Ottinger, Shoelson: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).

Dong, Du, Porter, Kolakowski, Lee, Mandarino, Fan, Yee, Liu, Mandarino: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).

ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).

Liu, Roth: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).

Details zu GRB10

Target: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Andere Bezeichnung: GRB10 (GRB10 Produkte)

Synonyme: grb10 antikoerper, zgc:91987 antikoerper, GRB10 antikoerper, grb-10 antikoerper, grb-ir antikoerper, irbp antikoerper, meg1 antikoerper, rss antikoerper, LOC100224775 antikoerper, 5730571D09Rik antikoerper, AI325020 antikoerper, Meg1 antikoerper, mKIAA0207 antikoerper, RGD1566234 antikoerper, GRB-IR antikoerper, Grb-10 antikoerper, IRBP antikoerper, MEG1 antikoerper, RSS antikoerper, growth factor receptor bound protein 10 antikoerper, growth factor receptor-bound protein 10a antikoerper, growth factor receptor bound protein 10 L homeolog antikoerper, growth factor receptor-bound protein 10 antikoerper, GRB10 antikoerper, grb10a antikoerper, grb10 antikoerper, grb10.L antikoerper, LOC100434903 antikoerper, Grb10 antikoerper

Hintergrund: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Molekulargewicht: 67231

NCBI Accession: NP_001001549, NP_001001550, NP_001001555, NP_005302

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2