GRIA4 Antikörper

Produktnummer ABIN498131

Produktdetails anti-GRIA4 Antikörper

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of GluR4 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu GRIA4

Target: GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))

Andere Bezeichnung: Glutamate Receptor 4 / GLUR4 (GRIA4 Produkte)

Synonyme: GLUR4 antikoerper, GLUR4C antikoerper, GLURD antikoerper, GluA4 antikoerper, GluR4 antikoerper, GluR4d antikoerper, GLUR4/D antikoerper, glur4 antikoerper, GluR-D antikoerper, Glur-4 antikoerper, Glur4 antikoerper, Gluralpha4 antikoerper, spkw1 antikoerper, DKFZp459P0616 antikoerper, glur4a antikoerper, gria4 antikoerper, iGluR4 antikoerper, ZfGluR4b antikoerper, fj46g06 antikoerper, glur4b antikoerper, wu:fj46g06 antikoerper, glutamate ionotropic receptor AMPA type subunit 4 antikoerper, glutamate receptor, ionotropic, AMPA 4 antikoerper, glutamate receptor, ionotropic, AMPA4 (alpha 4) antikoerper, glutamate receptor, ionotropic, AMPA 4a antikoerper, glutamate receptor, ionotropic, AMPA 4b antikoerper, GRIA4 antikoerper, gria4 antikoerper, Gria4 antikoerper, gria4a antikoerper, gria4b antikoerper

Hintergrund: G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: AMPA-selective glutamate receptor 4, GRIA4, GluA4, GluR-4, GluR-D, Glutamate receptor ionotropic AMPA4

Molekulargewicht: approx. 100 kDa

Gen-ID: 2893

NCBI Accession: NP_000820

UniProt: P48058

Pathways: PI3K-Akt Signalweg