LIN28A Antikörper

Produktnummer ABIN3031625

Produktdetails anti-LIN28A Antikörper

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LIN28A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Aufreinigung: Purified

Immunogen: LIN28A recombinant protein was used to produce this monoclonal antibody.

Klon: 55CT58-12-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Titration of the LIN28A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:200-1:2000,IHC (Paraffin): 1:50-1:200,Immunofluorescence: 1:10-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the LIN28A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu LIN28A

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Andere Bezeichnung: LIN28A (LIN28A Produkte)

Synonyme: CSDD1 antikoerper, LIN-28 antikoerper, LIN28 antikoerper, ZCCHC1 antikoerper, lin-28A antikoerper, AL024421 antikoerper, ENSMUSG00000070700 antikoerper, Gm10299 antikoerper, Lin-28 antikoerper, Lin28 antikoerper, Tex17 antikoerper, csdd1 antikoerper, lin-28 antikoerper, lin28 antikoerper, zcchc1 antikoerper, sb:cb650 antikoerper, zgc:55584 antikoerper, RGD1566408 antikoerper, lin-28 homolog A antikoerper, lin-28 homolog A (C. elegans) antikoerper, lin-28 homolog A S homeolog antikoerper, LIN28A antikoerper, Lin28a antikoerper, lin28a.S antikoerper, lin28a antikoerper

Hintergrund: LIN28A is a translational enhancer that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation.[UniProt]

UniProt: Q9H9Z2

Pathways: Stem Cell Maintenance