LIN28A Produkte
(Lin-28 Homolog A (C. Elegans) (LIN28A))
Kategorien
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
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Ausgewählte LIN28A Kategorien
LIN28A Antikörper
High quality antibodies with extensive validation data.
LIN28A ELISA Kits
Reliable ELISA kits for a wide range of species.
LIN28A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LIN28A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF, FACS, IHC (p)
Validierungen
- (6)
Kat. Nr.
ABIN655156
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, ICC
Validierungen
- (2)
- (3)
Kat. Nr.
ABIN968936
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN7268266
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LIN28A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6968296
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957482
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6957483
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LIN28A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7123766
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN667750
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309449
Menge
25 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LIN28A Produkten
: "Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer." in: Cell death discovery, Vol. 3, pp. 16105, (2017) (PubMed).: "A Rapid Induction Mechanism for Lin28a in Trophic Responses." in: Molecular cell, Vol. 65, Issue 3, pp. 490-503.e7, (2017) (PubMed).
: "Organoid models of human and mouse ductal pancreatic cancer. ..." in: Cell, Vol. 160, Issue 1-2, pp. 324-38, (2015) (PubMed).
: "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 232, Issue 2, pp. 487-97, (2005) (PubMed).
: "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9198-208, (2005) (PubMed).
Synonyme und alternative Namen zu LIN28A
lin-28 homolog A (LIN28A), lin-28 homolog A (C. elegans) (Lin28a), lin-28 homolog A S homeolog (lin28a.S), lin-28 homolog A (C. elegans) (lin28a), lin-28 homolog A (Lin28a), lin-28 homolog A (lin28a), AL024421, CSDD1, csdd1, ENSMUSG00000070700, Gm10299, LIN-28, Lin-28, lin-28, lin-28A, LIN28, Lin28, lin28, RGD1566408, sb:cb650, Tex17, ZCCHC1, zcchc1, zgc:55584Bezeichner auf Proteinebene für LIN28A
- RNA-binding protein LIN-28
- protein lin-28 homolog A
- zinc finger CCHC domain-containing protein 1
- zinc finger, CCHC domain containing 1
- testis expressed gene 17
- testis-expressed protein 17
- RNA-binding protein LIN-28A
- lin-28A
- RNA-binding protein lin-28
- Lin-28.1
- lin-28 homolog A (C. elegans)
- lin-28-like
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