LIMK2 Produkte
(LIM Domain Kinase 2 (LIMK2))
Kategorien
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte LIMK2 Kategorien
LIMK2 Antikörper
High quality antibodies with extensive validation data.
LIMK2 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIMK2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene LIMK2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, ELISA, IF, ICC
Validierungen
- (10)
Kat. Nr.
ABIN6256239
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (4)
Kat. Nr.
ABIN561676
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA, IF
Validierungen
- (3)
Kat. Nr.
ABIN7138860
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene LIMK2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN5592316
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN2870021
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Cow
Analytical Method
Validierungen
Kat. Nr.
ABIN2870017
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene LIMK2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570605
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309440
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1309442
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren LIMK2 Produkten
: "LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission." in: Cell death and differentiation, Vol. 21, Issue 7, pp. 1036-49, (2014) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin." in: The EMBO journal, Vol. 24, Issue 3, pp. 473-86, (2005) (PubMed).
: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).
: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).
: "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3577-82, (2000) (PubMed).
: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).
: "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics." in: Nature cell biology, Vol. 1, Issue 5, pp. 253-9, (1999) (PubMed).
Synonyme und alternative Namen zu LIMK2
LIM domain kinase 2 L homeolog (limk2.L), LIM domain kinase 2 (limk2), LIM domain kinase 2 (LIMK2), LIM domain kinase 2 (Limk2), LIM motif-containing protein kinase 2 (Limk2), 9430059K01, A930024P04Rik, C85310, LIMK, LIMK2, Limk2a, Limk2b, Link2, wu:fa97c09, wu:fk73e11, xlimk2, zgc:91990Bezeichner auf Proteinebene für LIMK2
- XLIM-Kinases2
- LIM domain kinase 2
- LIM domain kinase 2-like
- LIM motif-containing protein kinase 2
- LIMK-2
- LIM kinase 2
- LIM-containing protein kinase 2a
- LIM-containing protein kinase 2t
- Limk2t-1 and Limk2t-2
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