PRKAB2 Antikörper (AA 3-33)

Produktnummer ABIN3032387

Produktdetails anti-PRKAB2 Antikörper

Target: PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))

Bindungsspezifität: AA 3-33

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRKAB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 3-33 from human PRKAB2 was used as the immunogen for this AMPK beta 2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the AMPK beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the AMPK beta 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu PRKAB2

Target: PRKAB2 (Protein Kinase, AMP-Activated, beta 2 Non-Catalytic Subunit (PRKAB2))

Andere Bezeichnung: AMPK beta 2 (PRKAB2) (PRKAB2 Produkte)

Synonyme: prkab2 antikoerper, MGC64365 antikoerper, PRKAB2 antikoerper, DKFZp469M1118 antikoerper, 5730553K21Rik antikoerper, AW049591 antikoerper, BB124140 antikoerper, protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog antikoerper, protein kinase AMP-activated non-catalytic subunit beta 2 antikoerper, protein kinase, AMP-activated, beta 2 non-catalytic subunit antikoerper, prkab2.L antikoerper, PRKAB2 antikoerper, prkab2 antikoerper, Prkab2 antikoerper

Hintergrund: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.

UniProt: O43741

Pathways: AMPK Signaling, Warburg Effekt