KAP1 Antikörper (AA 699-835)

Produktnummer ABIN4952930

Produktdetails anti-KAP1 Antikörper

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Bindungsspezifität: AA 699-835

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids 699-835 of human TRIM28 were used as the immunogen for the TRIM28 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TRIM28 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the TRIM28 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu KAP1

Target: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Andere Bezeichnung: TRIM28 / KAP1 (TRIM28 Produkte)

Synonyme: KAP1 antikoerper, RNF96 antikoerper, TF1B antikoerper, TIF1B antikoerper, TRIM28 antikoerper, kap1 antikoerper, rnf96 antikoerper, tf1b antikoerper, tif1b antikoerper, AA408787 antikoerper, KAP-1 antikoerper, KRIP-1 antikoerper, Tif1b antikoerper, Tif1beta antikoerper, Kap1 antikoerper, Krip1 antikoerper, TIF1BETA antikoerper, tripartite motif containing 28 antikoerper, tripartite motif containing 28 L homeolog antikoerper, tripartite motif-containing 28 antikoerper, TRIM28 antikoerper, trim28.L antikoerper, Trim28 antikoerper

Hintergrund: Tripartite motif-containing 28, also known as transcriptional intermediary factor 1b (TIF1b) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications. Phosphorylation of KAP1 acts as a deactivator of the protein in many of its mechanisms while sumoylation acts as an activator.

UniProt: Q13263

Pathways: Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus