KAP1 Antikörper
Kurzübersicht für KAP1 Antikörper (ABIN6241957)
Target
Alle KAP1 (TRIM28) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Immunogen
- Recombinant Protein
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anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibody
TRIM28 Reaktivität: Human WB, ELISA, IF, IHC (p), RNAi Wirt: Maus Monoclonal 4E6 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (C-Term) antibodyVerified TRIM28 Reaktivität: Human IHC, ELISA, IF, FACS Wirt: Ziege Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 576-835) antibodyTRIM28 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (N-Term) antibodyTRIM28 Reaktivität: Human WB, IF, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 Reaktivität: Human WB, IF, IP, ICC, IHC (p), ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibodyTRIM28 Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 1D11 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (pSer824) antibodyTRIM28 Reaktivität: Human, Maus WB, IHC, IP, FACS, IF/ICC Wirt: Kaninchen Monoclonal BL-246-7B5 unconjugated Recombinant Antibody
anti-Tripartite Motif Containing 28 (TRIM28) (Ser824) antibodyTRIM28 Reaktivität: Human, Maus WB, IHC, IP, FACS, ICC Wirt: Kaninchen Monoclonal BL-248-2G6 unconjugated Recombinant Antibody
anti-Tripartite Motif Containing 28 (TRIM28) (pSer824) antibodyTRIM28 Reaktivität: Human, Maus WB, IP, ICC, IF/ICC, IHC (fp) Wirt: Kaninchen Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 699-835) antibodyTRIM28 Reaktivität: Human, Maus, Ratte WB, IHC, IF, FACS, ICC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- IP: 1:500. WB: 1:1000. IHC: 1:100. ICC: 1:100
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Lagerung
- 4 °C,-20 °C
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- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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Andere Bezeichnung
- KAP1 / TIF1 beta
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Hintergrund
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
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UniProt
- Q13263
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Pathways
- Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus
Target
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