KAP1 Antikörper (AA 576-835)
Kurzübersicht für KAP1 Antikörper (AA 576-835) (ABIN1683037)
Target
Alle KAP1 (TRIM28) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 576-835
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Sequenz
- PVLMALAEGP GAEGPRLASP SGSTSSGLEV VAPEGTSAPG GGPGTLDDSA TICRVCQKPG DLVMCNQCEF CFHLDCHLPA LQDVPGEEWS CSLCHVLPDL KEEDGSLSLD GADSTGVVAK LSPANQRKCE RVLLALFCHE PCRPLHQLAT DSTFSLDQPG GTLDLTLIRA RLQEKLSPPY SSPQEFAQDV GRMFKQFNKL TEDKADVQSI IGLQRFFETR MNEAFGDTKF SAVLVEPPPM SLPGAGLSSQ ELSGGPGDGP
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 576-835 of human KAP1/KAP1/TRIM28 (NP_005753.1).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:1000 - 1:3000,IHC,1:100 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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: "Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma." in: Cancer letters, Vol. 419, pp. 280-290, (2019) (PubMed).
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- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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Andere Bezeichnung
- TRIM28
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Hintergrund
- The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.,KAP1,PPP1R157,RNF96,TF1B,TIF1B,TRIM28,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Apoptosis,Ubiquitin,TRIM28
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Molekulargewicht
- 79 kDa/88 kDa
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Gen-ID
- 10155
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UniProt
- Q13263
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Pathways
- Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus
Target
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