ROCK2 Antikörper (AA 652-923)

Produktnummer ABIN4952426

Produktdetails anti-ROCK2 Antikörper

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Bindungsspezifität: AA 652-923

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ROCK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids 652-923 of human ROCK2 were used as the immunogen for the ROCK2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the ROCK2 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the ROCK2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu ROCK2

Target: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Andere Bezeichnung: ROCK2 (ROCK2 Produkte)

Synonyme: rocka-a antikoerper, xROK antikoerper, rock2 antikoerper, rok2 antikoerper, ROCK2 antikoerper, B230113H15Rik antikoerper, ROKalpha antikoerper, Rho-kinase antikoerper, Rock-II antikoerper, Rock2m antikoerper, mKIAA0619 antikoerper, ROCK-II antikoerper, ROK antikoerper, Rho-associated, coiled-coil containing protein kinase 2 L homeolog antikoerper, rho-associated, coiled-coil containing protein kinase 2a antikoerper, Rho associated coiled-coil containing protein kinase 2 antikoerper, Rho-associated, coiled-coil containing protein kinase 2 antikoerper, Rho-associated coiled-coil containing protein kinase 2 antikoerper, rock2.L antikoerper, rock2a antikoerper, ROCK2 antikoerper, Rock2 antikoerper

Hintergrund: Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.

UniProt: O75116

Pathways: Microtubule Dynamics, WNT Signalweg, Tube Formation