FOXA1 Antikörper (AA 372-472)

Produktnummer ABIN4949686

Produktdetails anti-FOXA1 Antikörper

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Bindungsspezifität: AA 372-472

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Keine Kreuzreaktivität: Ratte (Rattus)

Aufreinigung: Protein G affinity chromatography

Immunogen: A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.

Klon: FOXA1-1512

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FOXA1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/10^6 cells,IF: 1-2 μg/mL,WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL for 30 min at RT

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the FOXA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu FOXA1

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Andere Bezeichnung: FOXA1 (FOXA1 Produkte)

Synonyme: HNF3A antikoerper, TCF3A antikoerper, Hnf-3a antikoerper, Hnf3a antikoerper, Tcf-3a antikoerper, Tcf3a antikoerper, fkd7 antikoerper, forkhead-7 antikoerper, HNF3-alpha antikoerper, HNF3alpha antikoerper, fkh2 antikoerper, foxa1 antikoerper, hnf3a antikoerper, tFoxA1 antikoerper, tcf3a antikoerper, xfkh2 antikoerper, fkh antikoerper, FOXA1 antikoerper, Ci-fkh antikoerper, HNF-3a antikoerper, forkhead box A1 antikoerper, forkhead box A1 S homeolog antikoerper, forkhead homolog antikoerper, forkhead box A1 L homeolog antikoerper, FOXA1 antikoerper, Foxa1 antikoerper, foxa1 antikoerper, foxa1.S antikoerper, fkh antikoerper, foxa1.L antikoerper

Hintergrund: FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin as a pioneer factor. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

FOXA1 in breast cancer is highly correlated with ERalpha+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERalpha+ breast cancer, and its expression might identify ERalpha+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERalpha−, breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland. Expression in ERalpha−, cancers may identify a subset of tumors that is responsive to other endocrine therapies such as androgen receptor antagonist treatment. [Wiki]

Gen-ID: 3169

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis