SMAD2 Antikörper

Produktnummer ABIN4905224

Produktdetails anti-SMAD2 Antikörper

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD2 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktmerkmale: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human Smad2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 , IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu SMAD2

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Andere Bezeichnung: Smad2 (SMAD2 Produkte)

Synonyme: JV18 antikoerper, JV18-1 antikoerper, MADH2 antikoerper, MADR2 antikoerper, hMAD-2 antikoerper, hSMAD2 antikoerper, jv18 antikoerper, Xmad2 antikoerper, madh2 antikoerper, madr2 antikoerper, XSmad2 antikoerper, hmad-2 antikoerper, hsmad2 antikoerper, jv18-1 antikoerper, smad-2 antikoerper, fj43c06 antikoerper, wu:fj43c06 antikoerper, 7120426M23Rik antikoerper, Madh2 antikoerper, Madr2 antikoerper, Smad-2 antikoerper, mMad2 antikoerper, MAD homolog 2 antikoerper, Mothers against DPP homolog 2 antikoerper, SMAD 2 antikoerper, Smad2 antikoerper, SMAD family member 2 antikoerper, SMAD family member 2-Z antikoerper, SMAD family member 2 S homeolog antikoerper, SMAD2 antikoerper, SMAD2Z antikoerper, smad2 antikoerper, smad2.S antikoerper, Smad2 antikoerper

Gen-ID: 4087

UniProt: Q15796

Pathways: Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus