Ghrelin Antikörper (C-Term)

Produktnummer ABIN452691

Produktdetails anti-Ghrelin Antikörper

Target: Ghrelin (GHRL)

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Ghrelin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Spezifität: This antibody is expected to recognise all reported isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-QDILWEEAKEAPADK, from the C Terminus of the protein sequence according to NP_057446.1, NP_001128413.1, NP_001128416.1, NP_001128417.1, NP_001128418.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Detection Limit: 1/8000. Immunohistochemistry: 2-5 μg/mL. In paraffin embedded Human Placenta shows stainingof trophoblast cytoplasm.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu Ghrelin

Target: Ghrelin (GHRL)

Andere Bezeichnung: Ghrelin / GHRL (GHRL Produkte)

Synonyme: 2210006E23Rik antikoerper, Ghr antikoerper, MTLRP antikoerper, MTLRPAP antikoerper, m46 antikoerper, Gh1-1 antikoerper, GRHL antikoerper, MTLRP-AP antikoerper, GHR antikoerper, ghrelin antikoerper, ghrelin and obestatin prepropeptide antikoerper, ghrelin/obestatin prepropeptide antikoerper, Ghrl antikoerper, GHRL antikoerper, ghrl antikoerper

Hintergrund: Ghrelin was originally discovered as a preprohormone that stimulates the release of growth hormone from the anterior pituitary. Recent studies have shown that ghrelin, in concert with other hormones, helps to control both appetite and energy balance. The synthesis of Ghrelin takes place predominantly in epithelial cells of the stomach, although it is also produced in smaller quantities in the placenta, kidney, pituitary and hypothalamus. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect, induces adiposity, and stimulates gastric acid secretion, and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone (13 kDa), then proteolytically processed to yield a 28 amino acid peptide (3 kDa). Obestatin, an appetite suppressing peptide hormone, is also produced in the process. An interesting and unique modification is imposed on the ghrelin hormone during synthesis in the form of octanoic acid bound to one of its amino acids. This modification is necessary for biological activity.Synonyms: Appetite-regulating hormone, Ghrelin-27, Ghrelin-28, Growth hormone secretagogue, Growth hormone-releasing peptide, M46 protein, MTLRP, Motilin-related peptide, Obestatin

Gen-ID: 51738

NCBI Accession: NP_001128413

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour