Tamalin/GRASP Antikörper (N-Term)
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- Target Alle Tamalin/GRASP (GRASP) Antikörper anzeigen
- Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
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Bindungsspezifität
- N-Term
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Tamalin/GRASP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody is directed against Tamalin protein.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Rat.
Species reactivity (tested):Mouse. - Aufreinigung
- Affinity chromatography
- Immunogen
- Synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein
- Isotyp
- IgG
- Top Product
- Discover our top product GRASP Primärantikörper
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- Applikationshinweise
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ELISA: 1/4,000 - 1/20,000. Western Blot: 1/500 - 1/3,000. Immunoprecipitation: 1 μg.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.03 mg/mL (by UV absorbance at 280 nm)
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
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- Target
- Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
- Andere Bezeichnung
- GRASP (GRASP Produkte)
- Synonyme
- GRASP antikoerper, tamalin antikoerper, TAMALIN antikoerper, general receptor for phosphoinositides 1 associated scaffold protein antikoerper, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein antikoerper, GRASP antikoerper, grasp antikoerper, Grasp antikoerper
- Hintergrund
- Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domaincontaining protein that interacts with group 1 metabotropic glutamate receptors (mGluRs). The PDZ domaincontaining amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.Synonyms: GRP1-associated scaffold protein, General receptor for phosphoinositides 1-associated scaffold protein
- Gen-ID
- 56149
- NCBI Accession
- NP_062391
- UniProt
- Q9JJA9
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