Cyclin E2 Antikörper (C-Term)

Produktnummer ABIN401374

Produktdetails anti-Cyclin E2 Antikörper

Target: Cyclin E2 (CCNE2)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin E2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody is directed against Cyclin E2 pr

Kreuzreaktivität (Details): Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to amino acids at the carboxyl terminus of the Cyclin E2 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/20,000 - 1/85,000. Western Blot: 1/200 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.17 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu Cyclin E2

Target: Cyclin E2 (CCNE2)

Andere Bezeichnung: Cyclin E2 (CCNE2 Produkte)

Synonyme: ccne2 antikoerper, MGC53684 antikoerper, MGC132360 antikoerper, cb165 antikoerper, sb:cb165 antikoerper, zgc:86724 antikoerper, CCNE2 antikoerper, cyce2 antikoerper, CYCE2 antikoerper, cyclin E2 antikoerper, cyclin E2 L homeolog antikoerper, cyclin E1 L homeolog antikoerper, CCNE2 antikoerper, ccne2.L antikoerper, ccne2 antikoerper, ccne1.L antikoerper, Ccne2 antikoerper

Hintergrund: Cyclin E was first identified by its ability to rescue growth of yeast deficient in G1 Cyclins, indicating a role in G1 or G1/S transitions. Over-expression of Cyclin E has been observed in a variety of human tumors. Multiple isoforms of Cyclin E are expressed in tumors but not in normal tissues, suggesting a post-transcriptional regulation of Cyclin E. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27Kip1 and p21Cip1. The catalytic activity associated with Cyclin E2 complexes is cell cycle regulated and peaks at the G1/S transition. Unlike Cyclin E1, which is expressed in most proliferating normal and tumor cells, Cyclin E2 levels were low to undetectable in nontransformed cells and increased significantly in tumor-derived cells.Synonyms: CCNE2, Cyclin-E2, G1/S-specific cyclin-E2

Gen-ID: 12448

NCBI Accession: NP_001032211

UniProt: Q9Z238

Pathways: Zellzyklus, Mitotic G1-G1/S Phases