TLR6 Antikörper

Produktnummer ABIN377021

Produktdetails anti-TLR6 Antikörper

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR6 Antikörper ist unkonjugiert

Applikation: ELISA

Spezifität: Human Toll-like Receptor 6 (TLR6) The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLRs signal through adaptor molecules such as MyD88 leading to NF-B activation, c-Jun N-terminal kinase activation (JNK), cytokine secretion and the inflammatory response. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69 % identity. TLR6 recognizes mycoplasmal macrophage-activating lipopeptide- 2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.1-6

Produktmerkmale: Mouse Anti-Human TLR6-UNLB

Aufreinigung: Purified

Klon: 3B6

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: Enzyme-Linked-Immunosorbent-Assay (ELISA)
• Working Dilutions: ELISA Purified (UNLB) antibody 1:3,000 - 1:5,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu TLR6

Target: TLR6 (Toll-Like Receptor 6 (TLR6))

Andere Bezeichnung: TLR6 (TLR6 Produkte)

Synonyme: TLR1 antikoerper, TLR16 antikoerper, CD286 antikoerper, TLR-6 antikoerper, toll-like receptor 1 family member A antikoerper, toll like receptor 6 antikoerper, toll-like receptor 6 antikoerper, TLR1A antikoerper, TLR6 antikoerper, Tlr6 antikoerper

Hintergrund: The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLRs signal through adaptor molecules such as MyD88 leading to NF- λB activation, c-Jun N-terminal kinase activation (JNK), cytokine secretion and the inflammatory response. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69 % identity. TLR6 recognizes mycoplasmal macrophage-activating lipopeptide-2 kDa (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades