TNFRSF10B Antikörper

Produktnummer ABIN376980

Produktdetails anti-TNFRSF10B Antikörper

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF10B Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Spezifität: Human DR5

Produktmerkmale: Rabbit Anti-Human DR5-UNLB

Aufreinigung: Purified

Immunogen: Recombinant DR5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested WB , ICC
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 3 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L Immunoblotting Purified (UNLB) antibody 2 g/mL Immunocytochemistry Purified (UNLB) antibody 2 g/mL

Kommentare:

induction of apoptosis

Probenmenge: 0,2 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Andere Bezeichnung: DR5 (TNFRSF10B Produkte)

Synonyme: TNFRSF10B antikoerper, dr5 antikoerper, cd262 antikoerper, killer antikoerper, trick2 antikoerper, trickb antikoerper, xDR-M1 antikoerper, xDR-M2 antikoerper, ztnfr9 antikoerper, trailr2 antikoerper, trick2a antikoerper, trick2b antikoerper, CD262 antikoerper, DR5 antikoerper, KILLER antikoerper, KILLER/DR5 antikoerper, TRAIL-R2 antikoerper, TRAILR2 antikoerper, TRICK2 antikoerper, TRICK2A antikoerper, TRICK2B antikoerper, TRICKB antikoerper, ZTNFR9 antikoerper, Ly98 antikoerper, MK antikoerper, tumor necrosis factor receptor superfamily, member 10b antikoerper, tumor necrosis factor receptor superfamily member 10b S homeolog antikoerper, tumor necrosis factor receptor superfamily member 10b L homeolog antikoerper, tumor necrosis factor receptor superfamily member 10b antikoerper, TNF receptor superfamily member 10b antikoerper, Tnfrsf10b antikoerper, TNFRSF10B antikoerper, tnfrsf10b.S antikoerper, tnfrsf10b.L antikoerper, tnfrsf10b antikoerper

Hintergrund: DR5, also known as TRAIL-R2, TRICK2 and KILLER, is a widely expressed type I membrane member of the tumor necrosis (TNF) receptor family. Members of this family contain multiple cysteine-rich repeats in their extracellular domain and while the cytoplasmic region is less conserved, they do contain an intracellular 80 AA motif known as the ‘death domain' (DD). DR5 is a receptor for the cytotoxic ligand TRAIL which induces apoptosis and it is the cytoplasmic DD that is responsible for transducing the death process. DR5 has also been shown to activate NF- λB.

Pathways: p53 Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity