TNFRSF10B Antikörper (AA 233-440)

Produktnummer ABIN5518794

Produktdetails anti-TNFRSF10B Antikörper

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Bindungsspezifität: AA 233-440

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF10B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tumor necrosis factor receptor superfamily, member 10b
Protein Name: Tumor necrosis factor receptor superfamily member 10B

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DR5 recombinant protein (Position: K233-S440). Human DR5 shares 48.4% amino acid (aa) sequence identity with mouse DR5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-TNFRSF10B Antikörper (ABIN5518794)

Liu, Zuo, Wang, Chen, Yang, Wang, Zhu: "miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT." in: Oncotarget, Vol. 5, Issue 13, pp. 4959-71, (2014) (PubMed).

Details zu TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Andere Bezeichnung: TNFRSF10B (TNFRSF10B Produkte)

Synonyme: TNFRSF10B antikoerper, dr5 antikoerper, cd262 antikoerper, killer antikoerper, trick2 antikoerper, trickb antikoerper, xDR-M1 antikoerper, xDR-M2 antikoerper, ztnfr9 antikoerper, trailr2 antikoerper, trick2a antikoerper, trick2b antikoerper, CD262 antikoerper, DR5 antikoerper, KILLER antikoerper, KILLER/DR5 antikoerper, TRAIL-R2 antikoerper, TRAILR2 antikoerper, TRICK2 antikoerper, TRICK2A antikoerper, TRICK2B antikoerper, TRICKB antikoerper, ZTNFR9 antikoerper, Ly98 antikoerper, MK antikoerper, tumor necrosis factor receptor superfamily, member 10b antikoerper, tumor necrosis factor receptor superfamily member 10b S homeolog antikoerper, tumor necrosis factor receptor superfamily member 10b L homeolog antikoerper, tumor necrosis factor receptor superfamily member 10b antikoerper, TNF receptor superfamily member 10b antikoerper, Tnfrsf10b antikoerper, TNFRSF10B antikoerper, tnfrsf10b.S antikoerper, tnfrsf10b.L antikoerper, tnfrsf10b antikoerper

Hintergrund: TNFRSF10B(Tumor necrosis factor receptor superfamily, member 10b) is a human gene. It is also known as DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.By analysis of radiation hybrid panels, this gene is mapped to chromosome 8p22-p21. Northern blot analysis indicated that TRAILR2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.

Synonyms: CD262 antigen | Cytotoxic TRAIL receptor 2 | DR5 | Dr5 | Killer | KILLER | O14763 | TNFRSF10B | TR10B | trail r2 | trailr 2 | TRAILR2 | TRAIL-R2 | TRICK2 | TRICK2A | TRICK2B

Gen-ID: 8795

UniProt: O14763

Pathways: p53 Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity