GCH1 Antikörper (Internal Region)

Produktnummer ABIN375001

Produktdetails anti-GCH1 Antikörper

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser GCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody is expected to recognize all four isoforms.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide with sequence C-GKVHIGYLPNKQ, from the internal region of the protein sequence Genename: GCH1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/16000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Abstract: GCH1 Produkte

Synonyme: DYT14 antikoerper, DYT5 antikoerper, DYT5a antikoerper, GCH antikoerper, GTP-CH-1 antikoerper, GTPCH1 antikoerper, HPABH4B antikoerper, GTP-CH antikoerper, GTPCH antikoerper, Gch antikoerper, MGC89622 antikoerper, gch1a antikoerper, wu:fc16b10 antikoerper, zgc:195269 antikoerper, GTP cyclohydrolase 1 antikoerper, GTP cyclohydrolase 1-like antikoerper, GCH1 antikoerper, Gch1 antikoerper, gch1 antikoerper, Weevi_1190 antikoerper, Halhy_0838 antikoerper, Sinme_1220 antikoerper, Sphch_1077 antikoerper, LOC100136794 antikoerper

Hintergrund: GCH1 is a member of the GTP cyclohydrolase family. It is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.Synonyms: DYT5, GCH, GTP cyclohydrolase I, GTP-CH-I

Gen-ID: 2643, 9606

UniProt: P30793