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GCH1 Produkte

(GTP Cyclohydrolase 1 (GCH1))

Kategorien

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].

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Ausgewählte GCH1 Kategorien

GCH1 Antikörper

High quality antibodies with extensive validation data.

GCH1 ELISA Kits

Reliable ELISA kits for a wide range of species.

GCH1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GCH1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC (p), IP
Validierungen
  • (11)
  • (6)
Kat. Nr. ABIN561018
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF
Validierungen
  • (4)
Kat. Nr. ABIN7267525
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN302137
Menge 100 μg
Datenblatt Datenblatt

Empfohlene GCH1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1135670
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1135671
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method
Validierungen
Kat. Nr. ABIN1135672
Menge 96 tests
Datenblatt Datenblatt

Empfohlene GCH1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1354910
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1354912
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7422661
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren GCH1 Produkten

Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

Synonyme und alternative Namen zu GCH1

GTP cyclohydrolase 1 (GCH1), GTP cyclohydrolase 1 (Gch1), GTP cyclohydrolase 1 (gch1), GTP cyclohydrolase 1 (Weevi_1190), GTP cyclohydrolase 1 (Halhy_0838), GTP cyclohydrolase 1 (Sinme_1220), GTP cyclohydrolase 1 (Sphch_1077), GTP cyclohydrolase 1-like (LOC100136794), DYT5, DYT5a, DYT14, GCH, Gch, gch1a, GTP-CH, GTP-CH-1, GTPCH, GTPCH1, HPABH4B, MGC89622, wu:fc16b10, zgc:195269

Bezeichner auf Proteinebene für GCH1

  • GTP cyclohydrolase I
  • GTP-CH-I
  • dystonia 14
  • guanosine 5'-triphosphate cyclohydrolase I
  • GTP cyclohydrolase 1 (dopa-responsive dystonia)
  • GTP cyclohydrolase 1
  • GTP cyclohydrolase I (form A; N-terminus)
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