GCH1 Produkte
(GTP Cyclohydrolase 1 (GCH1))
Kategorien
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
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Ausgewählte GCH1 Kategorien
GCH1 Antikörper
High quality antibodies with extensive validation data.
GCH1 ELISA Kits
Reliable ELISA kits for a wide range of species.
GCH1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene GCH1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), IP
Validierungen
- (11)
- (6)
Kat. Nr.
ABIN561018
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN7267525
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN302137
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene GCH1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1135670
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1135671
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1135672
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene GCH1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1354910
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1354912
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN3121448
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren GCH1 Produkten
: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).
: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).
: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).
: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).
: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).
: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).
: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).
: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).
: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).
Synonyme und alternative Namen zu GCH1
GTP cyclohydrolase 1 (GCH1), GTP cyclohydrolase 1 (Gch1), GTP cyclohydrolase 1 (gch1), GTP cyclohydrolase 1 (Weevi_1190), GTP cyclohydrolase 1 (Halhy_0838), GTP cyclohydrolase 1 (Sinme_1220), GTP cyclohydrolase 1 (Sphch_1077), GTP cyclohydrolase 1-like (LOC100136794), DYT5, DYT5a, DYT14, GCH, Gch, gch1a, GTP-CH, GTP-CH-1, GTPCH, GTPCH1, HPABH4B, MGC89622, wu:fc16b10, zgc:195269Bezeichner auf Proteinebene für GCH1
- GTP cyclohydrolase I
- GTP-CH-I
- dystonia 14
- guanosine 5'-triphosphate cyclohydrolase I
- GTP cyclohydrolase 1 (dopa-responsive dystonia)
- GTP cyclohydrolase 1
- GTP cyclohydrolase I (form A; N-terminus)
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