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GCLM Produkte

(Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Kategorien

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008].

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Ausgewählte GCLM Kategorien

GCLM Antikörper

High quality antibodies with extensive validation data.

GCLM ELISA Kits

Reliable ELISA kits for a wide range of species.

GCLM Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GCLM Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation EIA, FACS, IF, IHC (p), WB
Validierungen
  • (5)
Kat. Nr. ABIN952478
Menge 0.4 mL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC, WB
Validierungen
  • (4)
Kat. Nr. ABIN7154002
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (4)
  • (3)
Kat. Nr. ABIN516058
Menge 100 μg
Datenblatt Datenblatt

Empfohlene GCLM ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6967069
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Rat
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6967070
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6956169
Menge 96 tests
Datenblatt Datenblatt

Empfohlene GCLM Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source
Validierungen
  • (2)
Kat. Nr. ABIN987261
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3081231
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3131414
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren GCLM Produkten

Cao, Poddar, Magtanong, Lumb, Mileur, Reid, Dovey, Wang, Locasale, Stone, Cole, Carette, Dixon: "A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity." in: Cell reports, Vol. 26, Issue 6, pp. 1544-1556.e8, (2019) (PubMed).

Zou, Wang, Peng, Wei: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).

Li, Sun, Liu, Zhao, Shao: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).

Lu, Samanta, Xiang, Zhang, Hu, Chen, Bullen, Semenza: "Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 33, pp. E4600-9, (2015) (PubMed).

Tomasi, Ryoo, Yang, Iglesias Ara, Ko, Lu: "Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice." in: Free radical biology & medicine, Vol. 68, pp. 148-58, (2014) (PubMed).

Chen, Jiang, Hu, Zhang: "The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis." in: Biological trace element research, Vol. 155, Issue 1, pp. 119-31, (2014) (PubMed).

Ramani, Tomasi, Yang, Ko, Lu: "Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." in: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).

Sharon, Mor, Golan-lev, Fainsod, Benvenisty: "Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 29, Issue 4, pp. 600-8, (2011) (PubMed).

Abel, Bubel, Simper, Powell, McClellan, Andreeff, MacLeod, DiGiovanni: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." in: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).

Hardwick, Fisher, Canet, Lake, Cherrington: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).

Synonyme und alternative Namen zu GCLM

glutamate-cysteine ligase regulatory subunit (PTRG_09814), glutamate cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (GCLM), glutamate-cysteine ligase, modifier subunit (gclm), glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L), glutamate-cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (Gclm), AI649393, Gcmc, Glclr, GLCLR, id:ibd3182, wu:fi24c07, zgc:55903

Bezeichner auf Proteinebene für GCLM

  • glutamate-cysteine ligase regulatory subunit
  • GCS light chain
  • gamma-ECS regulatory subunit
  • gamma-glutamylcysteine synthetase regulatory subunit
  • glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
  • glutamate--cysteine ligase regulatory subunit
  • glutamate-cysteine ligase modifier subunit
  • GSC light chain
  • glutamate--cysteine ligase modifier subunit
  • glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
  • glutamate-cysteine ligase modifier subunit delta2 alternative splicing
  • glutamate-cysteine ligase regulatory protein
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