ING2 Antikörper (C-Term)

Produktnummer ABIN374223

Produktdetails anti-ING2 Antikörper

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Bindungsspezifität: C-Term

Reaktivität: Human, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ING2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: C-DKSTEKTKKD RRSR

Spezifität: This antibody detetcs ING2 / ING1L at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):CowSpecies reactivity (tested):Human

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from C Terminus of the protein sequence according to NP_001555.1. Genename: ING2

Anwendungsinformationen

Applikationshinweise: Pedeux et al, ING2 regulates the onset of replicative senescence by induction ofp300-dependent p53 acetylation. Mol Cell Biol.2005 Aug,25(15): 6639-48. PMID: 16024799
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Details zu ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Andere Bezeichnung: ING2 / ING1L (ING2 Produkte)

Synonyme: ING1L antikoerper, p33ING2 antikoerper, 2810011M06Rik antikoerper, Ing1l antikoerper, Ing2b antikoerper, P33ING2 antikoerper, ING2 antikoerper, INGX antikoerper, wu:fe11c08 antikoerper, zgc:92346 antikoerper, ING1Lp antikoerper, ing2 antikoerper, xing2 antikoerper, inhibitor of growth family member 2 antikoerper, inhibitor of growth family, member 2 antikoerper, inhibitor of growth family member 2 S homeolog antikoerper, inhibitor of growth family member 2 L homeolog antikoerper, ING2 antikoerper, Ing2 antikoerper, ing2.S antikoerper, ing2 antikoerper, ing2.L antikoerper

Hintergrund: This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.Synonyms: Inhibitor of growth 1-like protein, Inhibitor of growth protein 2, p33ING2

Gen-ID: 3622

NCBI Accession: NP_001555

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagie, Negative Regulation of intrinsic apoptotic Signaling