ORAI3 Antikörper (N-Term)

Produktnummer ABIN372755

Produktdetails anti-ORAI3 Antikörper

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORAI3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Recognizes ORAI3, also known as Transmembrane Protein 142C, a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. This antibody is not expected to cross react with either ORAI1 or ORAI2.
Cellular Localization: Cell Membrane.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography.

Immunogen: ORAI3 antibody was raised against a 15 amino acid peptide from near the amino terminus of Human ORAI3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: Detects a band of approximately 35 kDa in A20 cell lysates. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu ORAI3

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Andere Bezeichnung: ORAI3 (ORAI3 Produkte)

Synonyme: ORAI3 antikoerper, TMEM142C antikoerper, 9930124N15 antikoerper, BC061259 antikoerper, Tmem142c antikoerper, RGD1306538 antikoerper, ORAI calcium release-activated calcium modulator 3 antikoerper, ORAI3 antikoerper, Orai3 antikoerper

Hintergrund: Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C

Molekulargewicht: 31 kDa

Gen-ID: 93129

NCBI Accession: NP_689501

UniProt: Q9BRQ5