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ORAI3 Antikörper (N-Term)

ORAI3 Reaktivität: Human, Ratte, Maus WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500425
  • Target Alle ORAI3 Antikörper anzeigen
    ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
    Bindungsspezifität
    • 13
    • 9
    • 9
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 25
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 22
    • 3
    Kaninchen
    Klonalität
    • 22
    • 3
    Polyklonal
    Konjugat
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ORAI3 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 17
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects ORAI3 at N-term. It is predicted to have no cross-reactivity to ORAI1 or ORAI2.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    ORAI3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human ORAI3.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
    Andere Bezeichnung
    ORAI3 (ORAI3 Produkte)
    Synonyme
    ORAI3 antikoerper, TMEM142C antikoerper, 9930124N15 antikoerper, BC061259 antikoerper, Tmem142c antikoerper, RGD1306538 antikoerper, ORAI calcium release-activated calcium modulator 3 antikoerper, ORAI3 antikoerper, Orai3 antikoerper
    Hintergrund
    Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C
    Gen-ID
    93129
    UniProt
    Q9BRQ5
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