ORAI3 Antikörper (C-Term)

Produktnummer ABIN6990192

Der Maus Monoklonal anti-ORAI3 Antikörper (Klon 1B4F1) (ABIN6990192) detektiert spezifisch ORAI3 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für ORAI3 Antikörper (C-Term) (ABIN6990192)

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ORAI3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 1B4F1

Produktdetails anti-ORAI3 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Immunogen: A 19 amino acid synthetic peptide from near the carboxy terminus of human ORAI3.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ORAI3 antibody can be used for detection of ORAI3 by Western blot at 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ORAI3 Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: ORAI3 monoclonal antibody can be stored at -20°C, stable for one year.

Details zu ORAI3

Target: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Andere Bezeichnung: ORAI3

Hintergrund: ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE, these may represent post-translationally modified ORAI 3.

Gen-ID: 93129

UniProt: Q9BRQ5