HIF1A Antikörper (AA 329-530)
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- Target Alle HIF1A Antikörper anzeigen
- HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
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Bindungsspezifität
- AA 329-530
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser HIF1A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Reacts with human HIF-1 alpha
- Kreuzreaktivität
- Maus, Rind (Kuh)
- Kreuzreaktivität (Details)
- Cross reacts with proteins from bovine, mouse and rat.
- Aufreinigung
- Purified (protein G)
- Immunogen
- Human HIF-1 alpha amino acids 329-530
- Klon
- ESEE122
- Isotyp
- IgG1
- Top Product
- Discover our top product HIF1A Primärantikörper
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- Applikationshinweise
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF10 μg/mL, IHC1:100-1:5000, IP 1:10-1:500, WB1:500-1:1000 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Tris-glycine, 150 mM NaCl, Sodium azide 0.01 %
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C/-80 °C
- Informationen zur Lagerung
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
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- Target
- HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
- Andere Bezeichnung
- Hypoxia-Inducible Factor 1-alpha (HIF1A Produkte)
- Synonyme
- hif1a antikoerper, AA959795 antikoerper, HIF1alpha antikoerper, MOP1 antikoerper, bHLHe78 antikoerper, HIF-1A antikoerper, HIF-1alpha antikoerper, HIF1 antikoerper, HIF1-ALPHA antikoerper, PASD8 antikoerper, HIF1-alpha antikoerper, hif-1a antikoerper, hypoxia inducible factor 1 alpha antikoerper, hypoxia inducible factor 1, alpha subunit antikoerper, hypoxia inducible factor 1 alpha subunit antikoerper, HIF (Hypoxia Inducible Factor) homologa antikoerper, hif-1a antikoerper, Hif1a antikoerper, HIF1A antikoerper, hif1a antikoerper, hif-1 antikoerper
- Hintergrund
- Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters.
- Gen-ID
- 3091
- UniProt
- Q16665
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, Warburg Effekt
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