NTRK3 Antikörper
Kurzübersicht für NTRK3 Antikörper (ABIN351087)
Target
Alle NTRK3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Rabbit antibody to TrkC
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Spezifität
- Specific for TrkC.
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Kreuzreaktivität
- Human, Maus, Ratte
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Kreuzreaktivität (Details)
- Other species not yet tested.
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Aufreinigung
- IgG
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Immunogen
- A synthetic peptide from rat TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.
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Isotyp
- IgG
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Applikationshinweise
- IHC. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
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Handhabung
- Avoid freeze and thaw cycles.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
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Haltbarkeit
- 12 months
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- NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
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Andere Bezeichnung
- TrkC
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Hintergrund
- FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1 PI-3 kinase and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
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UniProt
- Q03351
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Pathways
- RTK Signalweg, Neurotrophin Signalübertragung, Regulation of Cell Size
Target
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