Neurofibromin 1 Antikörper

Produktnummer ABIN317682

Produktdetails anti-Neurofibromin 1 Antikörper

Target: Neurofibromin 1 (NF1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurofibromin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of Neurofibromin protein.(region surrounding Arg1575)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Andere Bezeichnung: Neurofibromin (NF1 Produkte)

Synonyme: NFNS antikoerper, VRNF antikoerper, WSS antikoerper, CG8318 antikoerper, Dmel\\CG8318 antikoerper, NF-1 antikoerper, NF1 antikoerper, Nf-1 antikoerper, dNF1 antikoerper, nf1 antikoerper, fe06d03 antikoerper, hm:zehn0874 antikoerper, wu:fe06d03 antikoerper, zehn0874 antikoerper, AW494271 antikoerper, E030030H24Rik antikoerper, neurofibromin 1 antikoerper, Neurofibromin 1 antikoerper, neurofibromin 1a antikoerper, neurofibromin antikoerper, putative neurofibromin antikoerper, NF1 antikoerper, Nf1 antikoerper, nf1a antikoerper, LOC593418 antikoerper, LOC5570549 antikoerper, CpipJ_CPIJ011774 antikoerper, Smp_148460 antikoerper

Hintergrund: Neurofibromatosis type 1 (NF1), or von Reckinghausen neurofibromatosis, is one of the most common autosomal dominant disorders in humans. Early linkage analysis mapped the NF1 gene to chromosome 17. The predicted NF1 transcript encodes a 2818 amino acid protein designated NF1GRP. By sequence analysis, similarity has been demonstrated within a small region of NF1GRP and members of the Ras GAP gene family. Functionally, NF1GRP was shown by biochemical analysis involving RAS-GAP hydrolysis and functional complementation in yeast to further resemble GAP protein. The NF1 protein is expressed at relatively constant levels in a broad range of cell lines and tissues including brain, lung, liver, kidney, spleen, muscle and colon. Although little is known regarding the function of NF1GRP, the homology with the catalytic domain of proteins with GTPase activity suggests that the NF1GRP may also interact in vivo with Ras proteins.Synonyms: NF-1, NF1

Molekulargewicht: approx. 319 kDa

Gen-ID: 4763

NCBI Accession: NP_000258

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity