Neurofibromin 1 Antikörper

Produktnummer ABIN7254607

Produktdetails anti-Neurofibromin 1 Antikörper

Target: Neurofibromin 1 (NF1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neurofibromin 1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human NF1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:40-1:250, ELISA 1:500-1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.7 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Andere Bezeichnung: NF1 (NF1 Produkte)

Synonyme: NFNS antikoerper, VRNF antikoerper, WSS antikoerper, CG8318 antikoerper, Dmel\\CG8318 antikoerper, NF-1 antikoerper, NF1 antikoerper, Nf-1 antikoerper, dNF1 antikoerper, nf1 antikoerper, fe06d03 antikoerper, hm:zehn0874 antikoerper, wu:fe06d03 antikoerper, zehn0874 antikoerper, AW494271 antikoerper, E030030H24Rik antikoerper, neurofibromin 1 antikoerper, Neurofibromin 1 antikoerper, neurofibromin 1a antikoerper, neurofibromin antikoerper, putative neurofibromin antikoerper, NF1 antikoerper, Nf1 antikoerper, nf1a antikoerper, LOC593418 antikoerper, LOC5570549 antikoerper, CpipJ_CPIJ011774 antikoerper, Smp_148460 antikoerper

Hintergrund: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.NF1 (Neurofibromin 1) is a Protein Coding gene. Diseases associated with NF1 include Neurofibromatosis-Noonan Syndrome and Neurofibromatosis, Type 1. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and RET signaling. GO annotations related to this gene include binding and phosphatidylcholine binding.

UniProt: P21359

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity