CYP2D6 Antikörper

Produktnummer ABIN317680

Produktdetails anti-CYP2D6 Antikörper

Target: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2D6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CYP2D6

Target: CYP2D6 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 (CYP2D6))

Andere Bezeichnung: CYP2D6 (CYP2D6 Produkte)

Synonyme: CPD6 antikoerper, CYP2D antikoerper, CYP2D7AP antikoerper, CYP2D7BP antikoerper, CYP2D7P2 antikoerper, CYP2D8P2 antikoerper, CYP2DL1 antikoerper, CYPIID6 antikoerper, P450-DB1 antikoerper, P450C2D antikoerper, P450DB1 antikoerper, CYP2D42 antikoerper, MGC64445 antikoerper, cyp2d2 antikoerper, cyp2d6-a antikoerper, CYP2D6 antikoerper, cytochrome P450 family 2 subfamily D member 6 antikoerper, cytochrome P450, family 2, subfamily D, polypeptide 6 antikoerper, cytochrome 2D6 antikoerper, cytochrome P450 family 2 subfamily D member 6 S homeolog antikoerper, cytochrome P450 2D6 antikoerper, cytochrome P450 2D6-like antikoerper, CYP2D6 antikoerper, cyp2d6-b antikoerper, cyp2d6.S antikoerper, cyp2d6 antikoerper, LOC100988273 antikoerper

Hintergrund: The P450II family comprises at least 5 subfamilies, designated A through E by the system of nomenclature recommended by an international committee. The P450IID subfamily comprises at least 2 genes in the rat, one of which is highly specific for debrisoquine 4-hydroxylase activity. An association of this gene with lung cancer has been found. Enhanced CYP2D6 activity has been related to malignancies of the bladder, liver, pharynx, and stomach and, especially, to cigarette-smoking-induced lung cancer. The data suggests that enhanced CYP2D6-mediated metabolism of one or more dietary and other environmental agents, to form a reactive intermediate, plays a role in cancer initiation and/or promotion in various tissues. CYP2D6 polymorphism, which is responsible for the variation in metabolism of debrisoquine 4-hydroxylase, is important in the metabolism of more than 30 drugs and environmental chemicals, including as much as 20 % of all commonly prescribed drugs. The gene which encodes CYP2D6 maps to human chromosome 22q13.1Synonyms: CYP2DL1, CYPIID6, Cytochrome P450 2D6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase

Molekulargewicht: approx. 55 kDa

Gen-ID: 9606

UniProt: P10635