c-MYC Antikörper (C-Term)

Produktnummer ABIN3042673

Produktdetails anti-c-MYC Antikörper

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Bindungsspezifität: AA 421-439, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MYC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Myc proto-oncogene protein(MYC) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: RKRREQLKHK LEQLRNSCA

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Myc proto-oncogene protein(MYC) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: v-myc myelocytomatosis viral oncogene homolog(avian)
Protein Name: Myc proto-oncogene protein

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human c-Myc(421-439aa RKRREQLKHKLEQLRNSCA), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-c-MYC Antikörper (ABIN3042673)

Jiang, Guo, Xiao, Bian, Wang, Wang, Zhou, Cai, Zheng: "Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency." in: Oncotarget, Vol. 8, Issue 23, pp. 37694-37704, (2018) (PubMed).

Zhang, Fei, Li, Zhao, Yang, Qu, Zhang, Yin, Zhang: "The role of β-catenin in the initiation and metastasis of TA2 mice spontaneous breast cancer." in: Journal of Cancer, Vol. 8, Issue 11, pp. 2114-2123, (2017) (PubMed).

Xu, Li, Sun, Guo, Chu, Wei, Li, Yang, Liu, Yao, Zhang, Shen: "Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression." in: Oncotarget, Vol. 6, Issue 28, pp. 26161-76, (2016) (PubMed).

Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: "LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses." in: Antiviral research, Vol. 117, pp. 99-109, (2015) (PubMed).

Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: "Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ..." in: European journal of medicinal chemistry, Vol. 86, pp. 165-74, (2014) (PubMed).

Wang, Gu, Wan, Zhu, Qiu, Weng, Yu, He: "Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors." in: PLoS ONE, Vol. 8, Issue 2, pp. e52088, (2013) (PubMed).

Li, Tian, Wang, Yao, Zhang, Lu, Sun, Gao, Xiao, Liu: "Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC." in: PLoS ONE, Vol. 8, Issue 10, pp. e77829, (2013) (PubMed).

Yuan, Zhang, Cai, Ding, Wang, Chen, Wang, Yan, Lu: "Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer." in: Oncology reports, Vol. 29, Issue 6, pp. 2291-6, (2013) (PubMed).

Zhang, Lu, Yang, Li, Sun, Tao, Liu, Zhang, Ma: "HILI inhibits TGF-? signaling by interacting with Hsp90 and promoting T?R degradation." in: PLoS ONE, Vol. 7, Issue 7, pp. e41973, (2012) (PubMed).

Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, (2011) (PubMed).

Qin, Hua, Shuang, Wang, Cui: "Effects of matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro." in: Pharmaceutical biology, Vol. 48, Issue 3, pp. 275-81, (2010) (PubMed).

Wang, Huo, Li, Fu, Xue, Yang, Wen, Ding, Duan: "Osteogenic role of endosomal chloride channels in MC3T3-E1 cells." in: Molecular and cellular biochemistry, Vol. 342, Issue 1-2, pp. 191-9, (2010) (PubMed).

Liu, Liu, Bai, Li, Yang: "Molecular cloning, expression and subcellular distribution of an alternative splice variant of the porcine Sirt2 gene." in: Molecular biology reports, Vol. 37, Issue 3, pp. 1671-6, (2010) (PubMed).

Long, Sun, Hu, Liang, Wang, Zhang, Cao, Zhen, Cui, Liu: "Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer." in: Oncology reports, Vol. 22, Issue 5, pp. 1189-95, (2009) (PubMed).

Details zu c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung: Myc Proto-Oncogene protein (MYC Produkte)

Synonyme: MRTL antikoerper, MYCC antikoerper, bHLHe39 antikoerper, c-Myc antikoerper, CMYC antikoerper, c-myc antikoerper, C-MYC antikoerper, LOC100136746 antikoerper, ARC antikoerper, B430311C09Rik antikoerper, MYC antikoerper, NOP antikoerper, Nop30 antikoerper, RNCMYC antikoerper, mMyc antikoerper, AU016757 antikoerper, Myc2 antikoerper, Niard antikoerper, Nird antikoerper, cmyc antikoerper, zc-myc antikoerper, c-myc II antikoerper, myc-B antikoerper, myc2 antikoerper, myc1 antikoerper, CMyc antikoerper, zgc:55680 antikoerper, CG10798 antikoerper, D-Myc antikoerper, DM antikoerper, DMYc antikoerper, Dm antikoerper, Dmel\CG10798 antikoerper, Dmyc antikoerper, EG:BACN5I9.1 antikoerper, anon-WO03040301.171 antikoerper, bHLHe57 antikoerper, c-MYC antikoerper, d-myc antikoerper, dMYC antikoerper, dMyc antikoerper, dMyc1 antikoerper, da antikoerper, dm antikoerper, dm/dMyc antikoerper, dm/myc antikoerper, dmyc antikoerper, dmyc1 antikoerper, l(1)G0139 antikoerper, l(1)G0354 antikoerper, l(1)G0359 antikoerper, myc antikoerper, MYC proto-oncogene, bHLH transcription factor antikoerper, v-myc myelocytomatosis viral oncogene homolog antikoerper, nucleolar protein 3 (apoptosis repressor with CARD domain) antikoerper, myelocytomatosis oncogene antikoerper, MYC proto-oncogene, bHLH transcription factor a antikoerper, MYC proto-oncogene, bHLH transcription factor L homeolog antikoerper, MYC proto-oncogene, bHLH transcription factor S homeolog antikoerper, v-myc myelocytomatosis viral oncogene homolog (avian) antikoerper, MYC proto-oncogene, bHLH transcription factor b antikoerper, CG10798 gene product from transcript CG10798-RB antikoerper, MYC antikoerper, LOC100136746 antikoerper, Nol3 antikoerper, Myc antikoerper, myca antikoerper, myc.L antikoerper, myc.S antikoerper, mycb antikoerper

Hintergrund: C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol(2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

Synonyms: AU016757 antibody|Avian myelocytomatosis viral oncogene homolog antibody|bHLHe39 antibody|c Myc antibody|c Myc Epitope Tag antibody|c Myc Tag antibody|Class E basic helix-loop-helix protein 39 antibody|MRTL antibody|Myc antibody|Myc Epitope Tag antibody|Myc protein antibody|Myc proto oncogene protein antibody|Myc proto-oncogene protein antibody|MYC_HUMAN antibody|Myc2 antibody|Myelocytomatosis oncogene antibody|Niard antibody|Nird antibody|Oncogene Myc antibody|OTTHUMP00000158589 antibody|Proto-oncogene c-Myc antibody|RNCMYC antibody|Transcription factor p64 antibody|Transcriptional regulator Myc-A antibody|V-Myc avian myelocytomatosis viral oncogene homolog antibody|v-myc myelocytomatosis viral oncogene homolog(avian) antibody

UniProt: P01106

Pathways: p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt