NFKBIB Antikörper (AA 56-237)
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- Target Alle NFKBIB Antikörper anzeigen
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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Bindungsspezifität
- AA 56-237
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NFKBIB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- Antigen affinity
- Immunogen
- Human partial recombinant protein (AA 56-237) was used as the immunogen for this IkB beta antibody.
- Isotyp
- IgG
- Top Product
- Discover our top product NFKBIB Primärantikörper
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- Applikationshinweise
- The stated application concentrations are suggested starting amounts. Titration of the IkB beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Lagerung
- -20 °C
- Informationen zur Lagerung
- After reconstitution, the IkB beta antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Target
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
- Andere Bezeichnung
- IkB beta (NFKBIB Produkte)
- Synonyme
- NFKBIB antikoerper, IKB-beta antikoerper, IKappaBbeta antikoerper, IkB antikoerper, IkBb antikoerper, IKBB antikoerper, TRIP9 antikoerper, NFKB inhibitor beta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antikoerper, NFKBIB antikoerper, Nfkbib antikoerper
- Hintergrund
- NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the < a href=../search_result.php?search_txt=nfkb>NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with it and therebye trapping it in the cytoplasm. It has been found that in vivo, IkB beta serves both to inhibit and to facilitate the inflammatory response. Its degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as < a href=../search_result.php?search_txt=tnf alpha>TNF-alpha. Surprisingly, absence of IkB beta results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.
- Gen-ID
- 4793
- Pathways
- NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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