NME1 Antikörper (C-Term)
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- Target Alle NME1 Antikörper anzeigen
- NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NME1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Aufreinigung
- Antigen affinity
- Immunogen
- An amino acid sequence from the C-terminus of human NM23 (EELVDYTSCAQNWIYE) was used as the immunogen for this NM23 antibody.
- Isotyp
- IgG
- Top Product
- Discover our top product NME1 Primärantikörper
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- Applikationshinweise
- The stated application concentrations are suggested starting amounts. Titration of the NM23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Lagerung
- -20 °C
- Informationen zur Lagerung
- After reconstitution, the NM23 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- Target
- NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
- Andere Bezeichnung
- NM23 (NME1 Produkte)
- Synonyme
- AWD antikoerper, GAAD antikoerper, NB antikoerper, NBS antikoerper, NDKA antikoerper, NDPK-A antikoerper, NDPKA antikoerper, NM23 antikoerper, NM23-H1 antikoerper, AL024257 antikoerper, NM23-M1 antikoerper, NM23A antikoerper, NDPK-Z1 antikoerper, NM23-B antikoerper, NM23-Z1 antikoerper, ndpkz1 antikoerper, nm23b antikoerper, nme1 antikoerper, nme2 antikoerper, nme2b1 antikoerper, NME1 antikoerper, NME1-NME2 antikoerper, NM23-C1 antikoerper, ndpk-b antikoerper, ndpkb antikoerper, nm23-h2 antikoerper, nm23ndk antikoerper, puf antikoerper, NBR-A antikoerper, NBR-B antikoerper, NME1-1 antikoerper, nm23ndk-a antikoerper, NDK I antikoerper, NDPK I antikoerper, T30A10.80 antikoerper, T30A10_80 antikoerper, NDP kinase I antikoerper, NME/NM23 nucleoside diphosphate kinase 1 antikoerper, NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1 antikoerper, non-metastatic cells 1, protein (NM23A) expressed in antikoerper, NME/NM23 nucleoside diphosphate kinase 2 S homeolog antikoerper, NME/NM23 nucleoside diphosphate kinase 2 L homeolog antikoerper, nucleoside diphosphate kinase antikoerper, nucleoside diphosphate kinase 1 antikoerper, NME1 antikoerper, Nme1 antikoerper, nme2b.1 antikoerper, nme2.S antikoerper, nme2.L antikoerper, LOC547870 antikoerper, NDPK1 antikoerper, LOC107790563 antikoerper
- Hintergrund
- NME1 (NME/NM23 nucleoside diphosphate kinase 1), also called non-Metastatic protein 23 (NM23), is an enzyme that in humans encoded by the NME1 gene. The promoters of the mouse and human NME1 genes, like those of other NME genes, contain several binding sites for AP2, NF1, Sp1, LEF1, and response elements to glucocorticoid receptors. Immunofluorescence microscopy demonstrated colocalization of NME1 in nuclei of B cells expressing EBNA3C. Expression of EBNA3C reversed the ability of NME1 to inhibit migration of BL and breast carcinoma cells. NME1/NM23 bound SET and was released from inhibition by GZMA cleavage of SET. After GZMA loading or cytotoxic T lymphocyte attack, SET and NM23 translocated to the nucleus and SET was degraded, allowing NM23 to nick chromosomal DNA. Using a Drosophila model system,Dammai et al.(2003) showed that the Drosophila NME1 homolog, AWD, regulates trachea cell motility by modulating FGFR levels through a dynamin -mediated pathway.
- UniProt
- P15531
- Pathways
- Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process
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