NME1 Antikörper (N-Term)

Produktnummer ABIN2792090

Produktdetails anti-NME1 Antikörper

Target: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NME1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Dot Blot (DB)

Sequenz: ANCERTFIAI KPDGVQRGLV GEIIKRFEQK GFRLVGLKFM QASEDLLKEH

Homologie: Cow: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NME1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NME1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 152 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NME1

Target: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Andere Bezeichnung: NME1 (NME1 Produkte)

Synonyme: AWD antikoerper, GAAD antikoerper, NB antikoerper, NBS antikoerper, NDKA antikoerper, NDPK-A antikoerper, NDPKA antikoerper, NM23 antikoerper, NM23-H1 antikoerper, AL024257 antikoerper, NM23-M1 antikoerper, NM23A antikoerper, NDPK-Z1 antikoerper, NM23-B antikoerper, NM23-Z1 antikoerper, ndpkz1 antikoerper, nm23b antikoerper, nme1 antikoerper, nme2 antikoerper, nme2b1 antikoerper, NME1 antikoerper, NME1-NME2 antikoerper, NM23-C1 antikoerper, ndpk-b antikoerper, ndpkb antikoerper, nm23-h2 antikoerper, nm23ndk antikoerper, puf antikoerper, NBR-A antikoerper, NBR-B antikoerper, NME1-1 antikoerper, nm23ndk-a antikoerper, NDK I antikoerper, NDPK I antikoerper, T30A10.80 antikoerper, T30A10_80 antikoerper, NDP kinase I antikoerper, NME/NM23 nucleoside diphosphate kinase 1 antikoerper, NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1 antikoerper, non-metastatic cells 1, protein (NM23A) expressed in antikoerper, NME/NM23 nucleoside diphosphate kinase 2 S homeolog antikoerper, NME/NM23 nucleoside diphosphate kinase 2 L homeolog antikoerper, nucleoside diphosphate kinase antikoerper, nucleoside diphosphate kinase 1 antikoerper, NME1 antikoerper, Nme1 antikoerper, nme2b.1 antikoerper, nme2.S antikoerper, nme2.L antikoerper, LOC547870 antikoerper, NDPK1 antikoerper, LOC107790563 antikoerper

Hintergrund: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Alias Symbols: AWD, GAAD, NDPKA, NM23, NM23-H1, NB, NBS, NDKA, NDPK-A
Protein Interaction Partner: SREK1IP1, PID1, TNPO2, POLR1C, NME4, NME3, NME1, TUBG1, UBC, MDM2, ASB18, BMI1, CHRAC1, NME1-NME2, WDR1, THOP1, SORD, RBBP7, OXCT1, IDH1, FDPS, MAPK14, FBXO6, WDYHV1, NIF3L1, SOX30, FXR2, SMARCD1, NME2, CCND3, UROD, SOD1, MIF, ERG, EBNA-LP, HDAC5, STRAP,
Protein Size: 152

Molekulargewicht: 17 kDa

Gen-ID: 4830

NCBI Accession: NM_000269, NP_000260

UniProt: P22392

Pathways: Apoptose, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process