Cathepsin B Antikörper (AA 80-333)

Produktnummer ABIN3030330

Produktdetails anti-Cathepsin B Antikörper

Target: Cathepsin B (CTSB)

Bindungsspezifität: AA 80-333

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 80-333) was used as the immunogen for this Cathepsin B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Cathepsin B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Cathepsin B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Cathepsin B

Target: Cathepsin B (CTSB)

Andere Bezeichnung: Cathepsin B (CTSB Produkte)

Synonyme: APPS antikoerper, CPSB antikoerper, CB antikoerper, apps antikoerper, cpsb antikoerper, LOC692390 antikoerper, CTSB antikoerper, cathepsin B antikoerper, cathepsin B S homeolog antikoerper, CTSB antikoerper, Ctsb antikoerper, ctsb.S antikoerper, LOC692390 antikoerper

Hintergrund: Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimers disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that Cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimers disease. Overexpression has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

Gen-ID: 1508

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades