IL2RG Antikörper (Middle Region)

Produktnummer ABIN3029733

Produktdetails anti-IL2RG Antikörper

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL2RG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human IL-2 Receptor gamma subunit (HYWYKNSDNDKVQKC) was used as the immunogen for this IL-2 Receptor antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the IL-2 Receptor gamma antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the IL-2 Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu IL2RG

Target: IL2RG (Interleukin 2 Receptor, gamma (IL2RG))

Andere Bezeichnung: IL-2 Receptor (Gamma Subunit) (IL2RG Produkte)

Synonyme: Ab2-183 antikoerper, Cd132 antikoerper, CD132 antikoerper, CIDX antikoerper, IL-2RG antikoerper, IMD4 antikoerper, P64 antikoerper, SCIDX antikoerper, SCIDX1 antikoerper, [g]c antikoerper, gamma(c) antikoerper, gc antikoerper, interleukin 2 receptor subunit gamma antikoerper, interleukin 2 receptor subunit gamma L homeolog antikoerper, interleukin 2 receptor, gamma chain antikoerper, IL2RG antikoerper, il2rg.L antikoerper, Il2rg antikoerper

Hintergrund: Interleukin 2 receptor gamma, also known as Common gamma chain or CD132, is a cytokine recepter subunit that is common to the receptr complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 recepter. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte(white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, the IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL-2 receptor. Lymphocytes expressing the common gama chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation. The sharing of the gama subunit by several receptors explains why humans and mice that lack IL-2 entirely show milder symptoms than those with IL2RG deficiency.

UniProt: P31785

Pathways: JAK-STAT Signalweg, Growth Factor Binding