TP53BP1 Antikörper (C-Term)

Produktnummer ABIN3029398

Produktdetails anti-TP53BP1 Antikörper

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human 53BP1 (ERIGFKQHPKYKHDYVSH) was used as the immunogen for this 53BP1 antibody (100% mouse homology).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the 53BP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the 53BP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Andere Bezeichnung: 53BP1 (TP53BP1 Produkte)

Synonyme: TP53BP1 antikoerper, MGC160112 antikoerper, 53BP1 antikoerper, Tp53bp1 antikoerper, m53BP1 antikoerper, p202 antikoerper, Trp53bp1 antikoerper, tumor protein p53 binding protein 1 antikoerper, tumor suppressor p53-binding protein 1 antikoerper, tumor protein p53 binding protein 1 (predicted), 5 prime antikoerper, transformation related protein 53 binding protein 1 antikoerper, TP53BP1 antikoerper, tp53bp1 antikoerper, LOC100550605 antikoerper, Trp53bp1 antikoerper, Tp53bp1 antikoerper

Hintergrund: Tumor Protein p53-Binding Protein 1, also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against the protein in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. It was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

UniProt: Q12888

Pathways: DNA Reparatur