POLH Antikörper (AA 20-320)

Produktnummer ABIN3022621

Produktdetails anti-POLH Antikörper

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Bindungsspezifität: AA 20-320

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: QVEQRQNPHL RNKPCAVVQY KSWKGGGIIA VSYEARAFGV TRSMWADDAK KLCPDLLLAQ VRESRGKANL TKYREASVEV MEIMSRFAVI ERASIDEAYV DLTSAVQERL QKLQGQPISA DLLPSTYIEG LPQGPTTAEE TVQKEGMRKQ GLFQWLDSLQ IDNLTSPDLQ LTVGAVIVEE MRAAIERETG FQCSAGISHN KVLAKLACGL NKPNRQTLVS HGSVPQLFSQ MPIRKIRSLG GKLGASVIEI LGIEYMGELT QFTESQLQSH FGEKNGSWLY AMCRGIEHDP VKPRQLPKTI G

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human DNA polymerase eta (NP_006493.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu POLH

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Andere Bezeichnung: POLH (POLH Produkte)

Synonyme: POLH antikoerper, fc50a12 antikoerper, wu:fc50a12 antikoerper, zgc:136881 antikoerper, zgc:152642 antikoerper, RAD30 antikoerper, RAD30A antikoerper, XP-V antikoerper, XPV antikoerper, polymerase (DNA directed), eta S homeolog antikoerper, DNA polymerase eta antikoerper, polymerase (DNA directed), eta antikoerper, putative DNA polymerase eta antikoerper, polymerase (DNA directed), eta (RAD 30 related) antikoerper, polh.S antikoerper, POLH antikoerper, polh antikoerper, Tb10.70.6190 antikoerper, LINJ_21_0690 antikoerper, Polh antikoerper, LOC100443019 antikoerper

Hintergrund: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.,POLH,RAD30,RAD30A,XP-V,XPV,Epigenetics & Nuclear Signaling,POLH

Molekulargewicht: 46 kDa/78 kDa

Gen-ID: 5429

UniProt: Q9Y253

Pathways: DNA Reparatur