POLH Antikörper (AA 157-361)

Produktnummer ABIN3042492

Produktdetails anti-POLH Antikörper

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Bindungsspezifität: AA 157-361

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POLH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB in Human,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB in Human,Rat.
Gene Name: polymerase (DNA directed), eta
Protein Name: DNA polymerase eta

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human POLH recombinant protein (Position: A157-R361). Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu POLH

Target: POLH (Polymerase (DNA Directed), eta (POLH))

Andere Bezeichnung: POLH (POLH Produkte)

Synonyme: POLH antikoerper, fc50a12 antikoerper, wu:fc50a12 antikoerper, zgc:136881 antikoerper, zgc:152642 antikoerper, RAD30 antikoerper, RAD30A antikoerper, XP-V antikoerper, XPV antikoerper, polymerase (DNA directed), eta S homeolog antikoerper, DNA polymerase eta antikoerper, polymerase (DNA directed), eta antikoerper, putative DNA polymerase eta antikoerper, polymerase (DNA directed), eta (RAD 30 related) antikoerper, polh.S antikoerper, POLH antikoerper, polh antikoerper, Tb10.70.6190 antikoerper, LINJ_21_0690 antikoerper, Polh antikoerper, LOC100443019 antikoerper

Hintergrund: DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: DNA polymerase eta antibody|FLJ16395 antibody|FLJ21978 antibody|Polh antibody|POLH_HUMAN antibody|polymerase DNA directed eta antibody|RAD30 antibody|RAD30 homolog A antibody|RAD30A antibody|Xeroderma pigmentosum variant type protein antibody|XP V antibody|XPV antibody

Gen-ID: 5429

UniProt: Q9Y253

Pathways: DNA Reparatur