FRS2 Antikörper (Center)

Produktnummer ABIN2855603

Produktdetails anti-FRS2 Antikörper

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Bindungsspezifität: Center

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktmerkmale: Rabbit Polyclonal antibody to FRS2 (fibroblast growth factor receptor substrate 2)
FRS2 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FRS2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: H1299 , HeLaS3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-FRS2 Antikörper (ABIN2855603)

Bitzer, Spahn, Babaei, Horger, Singer, Schulze-Osthoff, Missios, Gatidis, Nann, Mattern, Scheble, Nikolaou, Armeanu-Ebinger, Schulze, Schroeder, Biskup, Beha, Claassen, Ruhm, Poso, Malek: "Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." in: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).

Details zu FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Andere Bezeichnung: FRS2 (FRS2 Produkte)

Synonyme: frs2 antikoerper, wu:fd21h10 antikoerper, zgc:91973 antikoerper, FRS2A antikoerper, FRS2alpha antikoerper, SNT antikoerper, SNT-1 antikoerper, SNT1 antikoerper, 4732458E18 antikoerper, C330018A15Rik antikoerper, Frs2alpha antikoerper, fibroblast growth factor receptor substrate 2 antikoerper, fibroblast growth factor receptor substrate 2b antikoerper, FRS2 antikoerper, frs2b antikoerper, Frs2 antikoerper

Hintergrund: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Cellular Localization: Endomembrane system

Molekulargewicht: 57 kDa

Gen-ID: 10818

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Signaling Events mediated by VEGFR1 and VEGFR2