ATF4 Antikörper
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- Target Alle ATF4 Antikörper anzeigen
- ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ATF4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human, Maus, Ratte
- Produktmerkmale
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Rabbit Polyclonal antibody to ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67))
ATF4 antibody - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human ATF4. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product ATF4 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Positive Control: HeLa (4ug/ml tunicamycin treatment for 16 hr)
Validation: Orthogonal
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.29 mg/mL
- Buffer
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization." in: Nature communications, Vol. 11, Issue 1, pp. 4254, (2020) (PubMed).
: "Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells." in: PLoS ONE, Vol. 9, Issue 5, pp. e97880, (2015) (PubMed).
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Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization." in: Nature communications, Vol. 11, Issue 1, pp. 4254, (2020) (PubMed).
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- Target
- ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
- Andere Bezeichnung
- activating transcription factor 4 (ATF4 Produkte)
- Synonyme
- CREB-2 antikoerper, CREB2 antikoerper, TAXREB67 antikoerper, TXREB antikoerper, ATF4 antikoerper, atf-4 antikoerper, creb-2 antikoerper, creb2 antikoerper, taxreb67 antikoerper, txreb antikoerper, atf4 antikoerper, wu:fj01c08 antikoerper, wu:fk30b04 antikoerper, zgc:85951 antikoerper, sb:eu681 antikoerper, wu:fb08f07 antikoerper, zgc:171702 antikoerper, Atf-4 antikoerper, C/ATF antikoerper, ATF4-I antikoerper, atf4-a antikoerper, atf4-b antikoerper, atf4-ii antikoerper, activating transcription factor 4 antikoerper, activating transcription factor 4 L homeolog antikoerper, activating transcription factor 4a antikoerper, activating transcription factor 4b antikoerper, activating transcription factor 4 S homeolog antikoerper, ATF4 antikoerper, atf4 antikoerper, Atf4 antikoerper, atf4.L antikoerper, atf4a antikoerper, atf4b antikoerper, atf4.S antikoerper
- Hintergrund
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This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
Cellular Localization: Cytoplasm , Cell membrane , Nucleus - Molekulargewicht
- 39 kDa
- Gen-ID
- 468
- UniProt
- P18848
- Pathways
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response
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