WNT4 Antikörper (Center)

Produktnummer ABIN2854927

Produktdetails anti-WNT4 Antikörper

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WNT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktmerkmale: Rabbit Polyclonal antibody to WNT4 (protein Wnt-4)
WNT4 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human WNT4. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:10000*

Kommentare:

Positive Control: 293T , HepG2 , WNT4 transfected 293T lysate , V5-human Wnt4-transfected 293T

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.78 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-WNT4 Antikörper (ABIN2854927)

Bai, Huo, Chen, Guo, Xu, Fang, Zhang, Zhang: "Effect of Huayu Tongluo Herbs on Reduction of Proteinuria via Inhibition of Wnt/β-Catenin Signaling Pathway in Diabetic Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2017, pp. 3054145, (2017) (PubMed).

Details zu WNT4

Target: WNT4 (Wingless-Type MMTV Integration Site Family, Member 4 (WNT4))

Andere Bezeichnung: WNT4 (WNT4 Produkte)

Synonyme: CG4698 antikoerper, DWnt-4 antikoerper, DWnt4 antikoerper, Dm DWnt4 antikoerper, Dmel\\CG4698 antikoerper, Dwnt4 antikoerper, Wnt antikoerper, Wnt-4 antikoerper, anon-EST:Liang-2.4 antikoerper, clone 2.4 antikoerper, wnt-4 antikoerper, wnt4 antikoerper, SERKAL antikoerper, WNT-4 antikoerper, Xwnt4 antikoerper, xwnt-4 antikoerper, zgc:136737 antikoerper, Wnt family member 4 antikoerper, Wnt oncogene analog 4 antikoerper, wingless-type MMTV integration site family, member 4 antikoerper, wingless-type MMTV integration site family member 4 S homeolog antikoerper, wingless-type MMTV integration site family, member 4a antikoerper, WNT4 antikoerper, Wnt4 antikoerper, wnt4.S antikoerper, wnt4a antikoerper

Hintergrund: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98 % amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molekulargewicht: 39 kDa

Gen-ID: 54361

Pathways: WNT Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cell-Cell Junction Organization, Tube Formation