APC Antikörper (pSer2054) (Alexa Fluor 594)
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- Target Alle APC Antikörper anzeigen
- APC (Adenomatous Polyposis Coli (APC))
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Bindungsspezifität
- pSer2054
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APC Antikörper ist konjugiert mit Alexa Fluor 594
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat,Dog,Cow,Sheep,Pig,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human APC around the phosphorylation site of Ser2054
- Isotyp
- IgG
- Top Product
- Discover our top product APC Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- APC (Adenomatous Polyposis Coli (APC))
- Andere Bezeichnung
- APC (APC Produkte)
- Synonyme
- dp2 antikoerper, dp3 antikoerper, fap antikoerper, fpc antikoerper, xapc antikoerper, dp2.5 antikoerper, AI047805 antikoerper, AU020952 antikoerper, AW124434 antikoerper, CC1 antikoerper, Min antikoerper, mAPC antikoerper, BTPS2 antikoerper, DP2 antikoerper, DP2.5 antikoerper, DP3 antikoerper, GS antikoerper, PPP1R46 antikoerper, RATAPC antikoerper, APC1 antikoerper, APC, WNT signaling pathway regulator antikoerper, adenomatous polyposis coli antikoerper, adenomatous polyposis coli protein, putative antikoerper, adenomatosis polyposis coli antikoerper, adenomatous polyposis coli L homeolog antikoerper, APC antikoerper, apc antikoerper, Smp_139190 antikoerper, Apc antikoerper, apc.L antikoerper
- Hintergrund
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Synonyms: APC phospho S2054, p-APC phospho S2054, Adenomatous Polyposis Coli, APC, CC1, DP2, DP2.5, DP3, FAP, FPC, GS, Protein APC.
Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
- Gen-ID
- 324
- Pathways
- WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization
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