COL4a3 Antikörper (N-Term)
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- Target Alle COL4a3 (COL4A3) Antikörper anzeigen
- COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Meerschweinchen, Pferd, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser COL4a3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- GPPGVPGSPG SSRPGLRGAP GWPGLKGSKG ERGRPGKDAM GTPGSPGCAG
- Homologie
- Guinea Pig: 85%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 85%
- Produktmerkmale
- This is a rabbit polyclonal antibody against COL4A3. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human COL4A3
- Top Product
- Discover our top product COL4A3 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1637 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))
- Andere Bezeichnung
- COL4A3 (COL4A3 Produkte)
- Synonyme
- zTumstatin antikoerper, [a]3(IV) antikoerper, alpha3(IV) antikoerper, collagen type IV alpha 3 chain antikoerper, collagen, type IV, alpha 3 antikoerper, COL4A3 antikoerper, col4a3 antikoerper, Col4a3 antikoerper
- Hintergrund
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Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.
Alias Symbols: -
Protein Interaction Partner: VHL, UBC, SERPINE2, OSM, MFAP2, FBLN2, FN1, DCN, CD93, MMP9, APP, SAA1, MATN2, TGFBI, CAMK2B, USH2A, ANTXR2, COL4A3BP, HABP2,
Protein Size: 1637 - Molekulargewicht
- 156 kDa
- Gen-ID
- 1285
- NCBI Accession
- NM_031362, NP_112730
- UniProt
- E7ENN2
- Pathways
- Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity
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