COL4a3 Antikörper (C-Term)

Produktnummer ABIN7266460

Produktdetails anti-COL4a3 Antikörper

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL4a3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Verwendungszweck: COL4A3 Rabbit pAb

Sequenz: SPGSCLEEFR ASPFLECHGR GTCNYYSNSY SFWLASLNPE RMFRKPIPST VKAGELEKII SRCQVCMKKR H

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1600 to the C-terminus of human COL4A3 (NP_000082.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu COL4a3

Target: COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))

Andere Bezeichnung: COL4A3 (COL4A3 Produkte)

Synonyme: zTumstatin antikoerper, [a]3(IV) antikoerper, alpha3(IV) antikoerper, collagen type IV alpha 3 chain antikoerper, collagen, type IV, alpha 3 antikoerper, COL4A3 antikoerper, col4a3 antikoerper, Col4a3 antikoerper

Hintergrund: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.,COL4A3,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Extracellular Matrix,Collagen,Immunology & Inflammation,Cardiovascular,Angiogenesis,Angiogenic inhibitory factors,COL4A3

Molekulargewicht: 135kDa/142kDa/158kDa/161kDa

Gen-ID: 1285

UniProt: Q01955

Pathways: Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity