RIC8A Antikörper (N-Term)

Produktnummer ABIN2787279

Produktdetails anti-RIC8A Antikörper

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Pferd, Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIC8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KLTERVGLYR ERSFPHDVQF FDLRLLFLLT ALRTDVRQQL FQELKGVRLL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RIC8A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RIC8A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 537 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RIC8A

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Andere Bezeichnung: RIC8A (RIC8A Produkte)

Synonyme: RIC8 antikoerper, AI114950 antikoerper, RIC-8 antikoerper, Ric8a antikoerper, Ric-8A antikoerper, Ric8 antikoerper, ric-8 antikoerper, ric8 antikoerper, synembryn antikoerper, xtric-8 antikoerper, zgc:92294 antikoerper, Syn antikoerper, ric8a antikoerper, ric8ab antikoerper, CG15797 antikoerper, DmRic8 antikoerper, Dmel\\CG15797 antikoerper, Ric-8 antikoerper, l(1)G0397 antikoerper, ric-8a antikoerper, ricc8aa antikoerper, fj97c10 antikoerper, synbl antikoerper, wu:fj97c10 antikoerper, RIC8 guanine nucleotide exchange factor A antikoerper, microRNA 6743 antikoerper, synembryn-A antikoerper, RIC8 guanine nucleotide exchange factor A L homeolog antikoerper, CG15797 gene product from transcript CG15797-RB antikoerper, synembryn antikoerper, RIC8 guanine nucleotide exchange factor A S homeolog antikoerper, Synembryn antikoerper, RIC8 guanine nucleotide exchange factor B antikoerper, RIC8A antikoerper, Ric8a antikoerper, ric8a antikoerper, MIR6743 antikoerper, Tsp_08768 antikoerper, ric8a.L antikoerper, LOC411841 antikoerper, ric8a.S antikoerper, ric-8 antikoerper, ric8b antikoerper

Hintergrund: RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Alias Symbols: MGC104517, MGC131931, MGC148073, MGC148074, RIC8, synembryn
Protein Interaction Partner: NECAB2, UBQLN1, RABAC1, UBC, EFEMP1, SDCBP, NUTM1, SARNP, WDR61, DPP7, PAPSS2, EZR, UBA1, RPL38, PYGB, PLCG1, MC1R, APEX1, GNAQ, XPO1, GNAI1, UBQLN4, ZNF585B, RIC8A, MAPK8IP3, GNA13, TERF1, GNAI3, GNAI2, GNAS, GNAO1, TUBB2A,
Protein Size: 537

Molekulargewicht: 60 kDa

Gen-ID: 60626

NCBI Accession: NM_021932, NP_068751

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Asymmetric Protein Localization