NR5A1 Antikörper (C-Term)

Produktnummer ABIN2780107

Produktdetails anti-NR5A1 Antikörper

Target: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR5A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VADQMTLLQN CWSELLVLDH IYRQVQYGKE DSILLVTGQE VELSTVAVQA

Homologie: Cow: 79%, Guinea Pig: 93%, Horse: 86%, Human: 86%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against Nr5a1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nr5a1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 462 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu NR5A1

Target: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Andere Bezeichnung: Nr5a1 (NR5A1 Produkte)

Synonyme: AD4BP antikoerper, ELP antikoerper, FTZ1 antikoerper, FTZF1 antikoerper, POF7 antikoerper, SF-1 antikoerper, SF1 antikoerper, SPGF8 antikoerper, SRXY3 antikoerper, Ad4BP antikoerper, ELP-3 antikoerper, Ftz-F1 antikoerper, Ftzf1 antikoerper, Ad4BP/SF-1 antikoerper, Ad4bp antikoerper, Sf-1 antikoerper, NR5A1 antikoerper, sf-1 antikoerper, elp antikoerper, sf1 antikoerper, ftz1 antikoerper, ad4bp antikoerper, ftzf1 antikoerper, SF-1/Ad4BP antikoerper, SI:zC167P9.2 antikoerper, ff1d antikoerper, nr5a2l antikoerper, nuclear receptor subfamily 5 group A member 1 antikoerper, nuclear receptor subfamily 5, group A, member 1 antikoerper, nuclear receptor subfamily 5 group A member 1 L homeolog antikoerper, nuclear receptor subfamily 6 group A member 1 antikoerper, nuclear receptor subfamily 5, group A, member 1b antikoerper, NR5A1 antikoerper, Nr5a1 antikoerper, nr5a1.L antikoerper, nr5a1 antikoerper, NR6A1 antikoerper, nr5a1b antikoerper

Hintergrund: Nr5a1 is a transcriptional activator. It seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. It binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Nr5a1 also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Nr5a1 binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Nr5a1 is activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Alias Symbols: Ad4BP, ELP, ELP-3, Ftz-F1, Ftzf1, SF-1, SF1
Protein Interaction Partner: Pitx1, Nfya, Pin1, Sumo1, Ubc, Egr1, Mir383, Ncoa1, Sumo2, Ppargc1a, Lhb, Tbx19, Sox9, Nr0b2, Nr0b1, Ncoa2,
Protein Size: 462

Molekulargewicht: 52 kDa

Gen-ID: 26423

NCBI Accession: NM_139051, NP_620639

UniProt: P33242

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Maintenance of Protein Location