TNFRSF10A Antikörper (C-Term)

Produktnummer ABIN971900

Produktdetails anti-TNFRSF10A Antikörper

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF10A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RAGTAGPGDA LYAMLMKWVN KTGRNASIHT LLDALERMEE RHAKEKIQDL

Homologie: Human: 100%, Mouse: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against TNFRSF10A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 468 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Andere Bezeichnung: TNFRSF10A (TNFRSF10A Produkte)

Synonyme: APO2 antikoerper, CD261 antikoerper, DR4 antikoerper, TRAILR-1 antikoerper, TRAILR1 antikoerper, TNFRSF10A antikoerper, TNF receptor superfamily member 10a antikoerper, tumor necrosis factor receptor superfamily member 26 antikoerper, tumor necrosis factor receptor superfamily, member 10a antikoerper, TNFRSF10A antikoerper, LOC510798 antikoerper

Hintergrund: This is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Alias Symbols: APO2, CD261, DR4, MGC9365, TRAILR-1, TRAILR1
Protein Interaction Partner: UBC, MARCH8, MARCH1, CFLAR, FADD, CUL3, TRAF2, CASP8, SQSTM1, TNFRSF10B, CBL, MOAP1, RASSF1, TNFRSF10D, TNFRSF10A, TNFSF10, MADD, BCL10, TRADD, RIPK1, DAP3, BTK, CD4, COL2A1, CASP10,
Protein Size: 468

Molekulargewicht: 50 kDa

Gen-ID: 8797

NCBI Accession: NM_003844, NP_003835

UniProt: O00220

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity