EED Antikörper (N-Term)

Produktnummer ABIN2776406

Produktdetails anti-EED Antikörper

Target: EED (Embryonic Ectoderm Development (EED))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EED Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: AKKQKLSSDE NSNPDLSGDE NDDAVSIESG TNTERPDTPT NTPNAPGRKS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against Eed. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 441 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu EED

Target: EED (Embryonic Ectoderm Development (EED))

Andere Bezeichnung: Eed (EED Produkte)

Synonyme: Xeed antikoerper, heed antikoerper, wait1 antikoerper, EED antikoerper, HEED antikoerper, WAIT1 antikoerper, zgc:112509 antikoerper, Xeed-B antikoerper, eed antikoerper, psXEED antikoerper, ENSMUSG00000039373 antikoerper, l(7)5Rn antikoerper, l7Rn5 antikoerper, lusk antikoerper, Xeed-A antikoerper, embryonic ectoderm development antikoerper, embryonic ectoderm development S homeolog antikoerper, microRNA 6755 antikoerper, embryonic ectoderm development L homeolog antikoerper, eed antikoerper, EED antikoerper, eed.S antikoerper, MIR6755 antikoerper, Eed antikoerper, eed.L antikoerper

Hintergrund: Eed is a polycomb group (PcG) protein. It is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. Eed plays a role in X chromosome inactivation (XCI), in which one of the two X chromosomes in female mammals is transcriptionally silenced to equalize X-linked gene dosage with XY males. Eed is required for stable maintenance of XCI in both embryonic and extra-embryonic tissues. Eed may prevent transcriptional activation of facultative heterochromatin during differentiation. Eed is required for development of secondary trophoblast giant cells during placental development. Eed may regulate hippocampal synaptic plasticity in the developing brain.
Alias Symbols: ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
Protein Interaction Partner: Ezh2, Suz12, Rab3gap1, Ddx47, Nop10, Nip7, Bola2, Tmem14c, Uqcr10, Eif3f, Cbwd1, Smc5, Etf1, Svil, Fbxo11, Srsf7, Safb, Safb2, Abcf1, Bag6, C330027C09Rik, Pak2, Pphln1, Ttll12, Sun2, Tomm22, Eif3l, E430025E21Rik, Eny2, Dcaf13, Trio, Ccar2, Fermt2, Vps41,
Protein Size: 441

Molekulargewicht: 50 kDa

Gen-ID: 13626

NCBI Accession: NM_021876, NP_068676

UniProt: Q921E6