CD79a Antikörper (AA 208-222) (PE)
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- Target Alle CD79a (CD79A) Antikörper anzeigen
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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Bindungsspezifität
- AA 208-222
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Schwein, Huhn, Meerschweinchen, Pferd, Kaninchen, Hund, Non-Human Primate
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD79a Antikörper ist konjugiert mit PE
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Kreuzreaktivität (Details)
- Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken
- Aufreinigung
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogen
- Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
- Klon
- HM47
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product CD79A Primärantikörper
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- Applikationshinweise
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.
- Kommentare
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." in: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).
: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." in: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).
: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." in: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).
: "B-cell markers in lymphocyte predominance Hodgkin disease." in: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
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- Target
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
- Andere Bezeichnung
- CD79a (CD79A Produkte)
- Synonyme
- CD79A antikoerper, Ig-alpha antikoerper, Iga antikoerper, Igalpha antikoerper, Ly-54 antikoerper, Ly54 antikoerper, mb-1 antikoerper, IGA antikoerper, MB-1 antikoerper, IG-alpha antikoerper, CD79a molecule antikoerper, CD79A antigen (immunoglobulin-associated alpha) antikoerper, Cd79a molecule-like antikoerper, CD79A antikoerper, Cd79a antikoerper, Cd79al antikoerper
- Hintergrund
- CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
- Gen-ID
- 973
- UniProt
- P11912
- Pathways
- BCR Signaling
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